Research Projects
Dr. Sudesh Prabhakar has led and participated in numerous high-impact research initiatives, both nationally and internationally. His research focuses on neurological disorders, gene expression, neuropharmacology, stem cell therapy, and the neuroprotective effects of traditional medicines like Bacopa Monniera (Brahmi). Many of these studies have been supported by esteemed institutions including NIH (USA), ICMR, DBT, CSIR, and DST.
Stem Cell Therapy for Neurological Disorders
Led multiple groundbreaking studies on the use of autologous bone marrow-derived stem cells for treating motor neuron disease, stroke, and retinal injury.
Genetic Insights into Parkinson’s and ALS
Investigated the molecular and genetic markers such as Parkin gene mutations and VEGF-A/CCL2 expression, contributing to early diagnosis and targeted therapies in neurodegenerative diseases.
Brahmi in Neuroprotection
Conducted clinical and experimental studies proving the neuroprotective and memory-enhancing effects of traditional Ayurvedic medicine Bacopa Monniera.
Therapy for acute ischemic stroke
Principal Investigator in a landmark multi-institutional study on intravenous stem cell therapy for acute ischemic stroke, funded by the Department of Biotechnology (DBT), India.
International Research Projects
National Institute of Health (NIH), Maryland, USA
- 2004 - Marijuana Abuse: Cognition, Neuroimaging, Endocrines | Role: Principal Investigator
- 2006 – HIV-1 Clade C Progression and NeuroAIDS | Role: Principal Investigator
National Research Projects
Department of Biotechnology (DBT) – Sponsored Research
Study of Molecular and Genetic Basis of Traditional Cognition Enhancing Drugs (Brahmi)
Principal Investigator – Focused on Bacopa Monniera (Brahmi) and memory lossAssessment of Marrow-Derived Stem Cell Implantation in Brain Stroke Mouse Model
Principal InvestigatorIntravenous Autologous Bone Marrow Stem Cell Therapy for Acute Ischemic Stroke
Principal Investigator – Multi-institutional studyExpression Analysis of VEGF-A, CCL2 & SOD1 in ALS Patients
Principal InvestigatorBone Marrow Stem Cell Incorporation in Laser-Injured Retina (Mouse Model)
Co-Investigator
Indian Council of Medical Research (ICMR)
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Parkin Gene Mutations in Juvenile & Early-Onset Parkinsonism
Principal Investigator -
Prothrombotic States in Ischemic Stroke – Indian Population
Principal Investigator -
Neuroprotective Effect of Bacopa Monniera in Ischemic Brain Injury
Principal Investigator -
Stem Cell Therapy for Retinal Neuron Rescue (Mouse Model)
Principal Investigator -
Envelope Gene & Cytokine Response in Japanese Encephalitis Patients
Principal Investigator -
Genetic Screening for CCL-2 & CCR-1 Mutations in ALS
Principal Investigator -
VEGF-A, CCL2 & sFlt Expression in ALS – Clinical Correlation
Principal Investigator
CSIR – Council of Scientific & Industrial Research
VEGF-A, CCL2 & sFlt-1 in ALS Patients
Co-InvestigatorMCP-1 & VEGF in Atherosclerotic Carotid Plaques
Co-Investigator
Department of Atomic Energy (DAE)
- CFH Gene Polymorphism in AMD and Alzheimer’s Disease
Co-Investigator
Department of Science & Technology (DST)
Genetic Polymorphism Study in AMD and Alzheimer’s Patients
Co-Investigator
Local Initiatives
Migraine Nasal Spray LLL-2011 – Phase III Trial
Principal InvestigatorSafinamide for Parkinson’s Disease (50/100 mg) – Phase III
Principal InvestigatorNeuroPath IS System for Acute Ischemic Stroke
Principal InvestigatorBG00012 for Relapsing–Remitting Multiple Sclerosis
Co-InvestigatorDesmoteplase for Acute Ischemic Stroke – Phase III
Co-InvestigatorBlood Pressure Management in Intracerebral Hemorrhage – Global Trial
Principal Investigator
PGI / Departmental Research Projects - 1978 - 2014
- Pyogenic meningitis – A retrospective analysis from 1970-1976.
- Non compressive myelopathy – A prospective study.
- Continuous muscle fibre activity – A clinical, electrophysiological and biochemical study.
- Stroke in Young – Immunological studies and electron microscope studies of platelets.
- Polymyositis – A Clinical, electrophysiological and histopathological study of 25 cases.
- Clinical, electrophysiological, immunological and biological studies in post-conjunctivitis neurologic complications.
- Myasthenia Gravis – A clinical and electrophysiological study.
- Clinical, electrophysiological and radiological study of wasted hand syndrome.
- Pattern of motor neurone disease in North India.
- Pattern of spinocerebellar degeneration in North India.
- Clinical profile of non inflammatory primary muscle diseases.
- Brain stem and visual evoked responses in spinocerebellar degeneration.
- Biochemical and electrophysiological studies in motor neurone disease.
- Study of extracranial criteria in stroke using Doppler arterial scan.
- Efficacy of cysticidal drugs (Praziquantel and Albendozole) in treatment of neurocysticercosis.
- Vanishing radiological lesions in epilepsy.
- Primary sensory neurone abnormality and serum Vitamin E in spinocerebellar degeneration.
- Intravenous Lignocaine for status epilepticus.
- Glucocorticoids in adults pyogenic meningitis. A randomised prospective trial.
- Auditory function after lumbar puncture.
- Efficacy of neuromapping in partial seizures.
- E.E.G., brain mapping, and C.T. in cases of stroke. A comparative study.
- Clinical and neurophysiological evaluation of scleroderma patients having CNS involvement and psychiatric manifestations.
- Cerebrovascular complications in Pyogenic meningitis in adult. A clinical and radiological study.
- Immunological profile : single small enhancing CT lesions vs neurocysticercosis.
- Electrophysiological, vascular and psychometric studies in migraine.
- Idebenon Clinical Trial in cases of cerebrovascular disorders. – Co-Investigator
- Incidence of HTLV-1 antibodies in patients with non-compressive myelopathy
- Clinical and electrophysiological evaluation of myoclonic epilepsy in India.
- Seizure in acute strokes. Management Strategy.
- Treatment seeking behaviour and psychosocial dysfunctioning in adult epileptics.
- Clinical and electrophysiological evaluation of peripheral nerves in Thyrotoxicosis.
- Central nervous system complications during induction therapy of childhood lymphoreticular malignancy.
- Clinical and electrophysiological aspects of neuromuscular changes, before and after induction therapy of childhood lymphoreticular malignancy.
- Parkinson’s disease – A study of changes P-300 potential in relation to therapy and cognition.
- Non haemorrhagic stroke : Predicting prognosis by transcranial magnetic stimulation.
- Oligoclonal bands in Multiple sclerosis
- Study of complicated Migraine.
- Transcranial and Cervical Magnetic Stimulation in Amyotrophic Lateral Sclerosis and Cervical Myelopathy.
- Auditory Event related P-300 potentials and peripheral nerve conduction studies in Liver cirrhosis.
- Effect of Sodium Valproate as prophylactic agent in migraine.
- INH induced peripheral neuropathy – electrophysiological study.
- Small single enhancing CT lesion (SSECTL): Alteration in cognition P300 and transcranial magnetic stimulation (TCMS).
- Identification and characterisation of differentially expressed gene transcripts in DMD/BMD patients
- Cognition and cerebral perfusion SPECT in Parkinson’s disease
- The clinical spectrum of afferent visual pathway defects in Migraine.
- A comparative study of Bell’s palsy treatment with acyclovir and prednisolone compared with prednisolone alone : A randomized blinded clinical and electrophysiological study
- Spectrum of peripheral neuropathy in Rheumatoid Arthritis.
- Multifocal Dystonias – Aetiopathological factors
- Writer’s Cramp – Clinical variants and response to Botulinum toxin
- Clinical Profile and demography of Dystonias
- Confirmation of seizure semiology by Video EEG
- Evaluation of Epilepsy related physical injuries
- The contribution of carotid atherosclerosis disease in young stroke patients with a Prothrombotic State
- A comparative study of Bell’s palsy treatment with acyclovir and prednisolone compared with prednisolone alone : A randomized blinded clinical and electrophysiological study
- Spectrum of peripheral neuropathy in Rheumatoid Arthritis.
- Establishment of NMDA induced retinal injury mouse model.
- Role of VEGF on the ciliary epithelial cell proliferation and its effect on the expression of Notch, Jagged, β catenin, SSEA1 and N Cadherin.
- Assessment of bone marrow derived Lin- Sca-1+ stem cell implantation in experimentally induced stroke related retinal ischemia mouse model.
- The effect of human umbilical cord blood derived Lineage negative stem cells in reversal of amyloid β peptide induced memory loss in mice.
- Role of autologous bone marrow derived stem cell therapy in management of patients with motor neuron disease : A Pilot Study
- Role of autologous bone marrow derived Stem cell therapy in management of patients with Motor Neuron Disease : A pilot study.